Zhefeng Guo

Zhefeng Guo is an Associate Professor in the Department of Neurology at UCLA School of Medicine, specializing in structural biology and biochemistry of amyloid-related neurodegenerative diseases. His research focuses on understanding the structural mechanisms of amyloid fibril formation in Alzheimer's, Parkinson's, and prion diseases.

• Structural characterization of amyloid fibrils
• Development of EPR methods for protein dynamics
• Investigation of aggregation mechanisms and diagnostics

The Guo Lab employs advanced techniques like electron paramagnetic resonance (EPR), X-ray crystallography, and protein engineering to elucidate amyloid structures and their pathological transitions. Recent work explores conformational ensembles, fibril polymorphism, and membrane interactions affecting aggregation.

Key research trends include amyloid structural heterogeneity, oligomer-fibril dynamics, and molecular mechanisms of neurotoxic aggregates. The lab actively investigates therapeutic strategies targeting amyloid formation through compounds like EGCG.