Yun Wu

Professor Yun Wu is a faculty member in the Department of Biomedical Engineering at the School of Engineering and Applied Sciences, University at Buffalo. She leads the Engineered Theranostics Laboratory, focusing on nanotechnology-enabled solutions for cancer detection and treatment. Her research integrates engineering principles with biomedical applications.

• PhD in Chemical and Biomolecular Engineering from The Ohio State University (2009)
• Postdoctoral work at Ohio State's Nanoscale Science and Engineering Center (2009-2013)
• Assistant/Associate/Full Professor at University at Buffalo (2013-present)

Yun Wu's research spans cancer theranostics through:

• Development of multifunctional nanoparticles for drug/gene delivery
• Exosome-based biosensor platforms for liquid biopsy
• Microfluidic methods for nanoparticle synthesis
• Targeted cancer therapies overcoming drug resistance
• Biodegradable zwitterionic polymers as PEG alternatives
• Surface plasmon resonance biosensors for protein/RNA detection

Her 15 most recent publications demonstrate expertise in:

• Exosome isolation and biomarker analysis
• Lipoplex nanoparticle engineering
• Multi-drug delivery systems
• Photoacoustic and fluorescence imaging
• Pharmacokinetic modeling
• Clinical translation of nanotherapeutics

Current research grants include:

• $3.1M NCI grant for Exo-PROS lung cancer detection (2022-2027)
• $2.4M NIBIB project on zwitterionic polymer-drug conjugates (2023-2027)
• $0.4M NCI grant for exosomal glycoantigen biomarkers (2022-2024)
• Co-investigator in $0.9M NHLBI fibrosis-on-chip system (2020-2023)

Lab members include PhD, MS, and undergraduate researchers. Collaborations exist with Roswell Park Comprehensive Cancer Center and Mayo Clinic clinicians.