Yu-Wen Alvin Huang

Yu-Wen Alvin Huang is the James and Dorothy Goodman Assistant Professor of Molecular Biology, Cell Biology and Biochemistry at Brown University since 2019. His research focuses on neuron-glial interactions in neurocognitive disorders like Alzheimer's disease and Angelman syndrome, using stem cell technologies and iPSC models.

• Department of Molecular Biology, Cell Biology and Biochemistry
• Department of Neurology
• Carney Institute for Brain Science
• Center for Translational Neuroscience

Research Interests: He investigates molecular mechanisms of neurodegeneration and brain aging, emphasizing astrocyte-neuron interactions and signaling pathways (e.g., CHI3L1, ApoE). His lab develops novel therapeutic approaches targeting these pathways.

Publications: Recent work includes studies on CHI3L1's role in Alzheimer's, TrkB/PSD-95 signaling in Angelman syndrome, and autophagy's impact on neurocognitive outcomes. Collaborations span neuroinflammation, iPSC modeling, and neurovascular biology.

Awards & Grants: NIH/NIA R00, R21, R01; Alzheimer’s Association Award; Carney Institute Innovation Awards; BrightFocus Foundation fellowship.