About
Prof. Dr. Yoko Yamakoshi is a Lecturer at the Department of Chemistry and Applied Biosciences at ETH Zürich, leading the Gruppe Yamakoshi. Her research focuses on fullerene chemistry, photodynamic therapy, and nanomaterials for biomedical applications. She specializes in designing water-soluble fullerene conjugates for targeted drug delivery and imaging, particularly in atherosclerosis diagnostics and cancer therapy.
Her work emphasizes reactive oxygen species (ROS) generation mechanisms, enzyme-responsive materials, and AFM-based single-molecule studies. Notable contributions include LDL-mimetic nanoparticles for MRI contrast enhancement and tripod-C60 functionalized AFM tips for DNA origami manipulation. Yamakoshi's interdisciplinary approach spans materials science, biochemistry, and medical imaging.
Recent research highlights include conditionally activated ROS probes for cancer diagnostics, fullerene-peptide conjugates with enhanced photocytotoxicity, and Gd(III)-porphyrin complexes for dual MRI/photodynamic applications. Her lab actively explores fullerene derivatives' structural properties and their implications for biological and nanotechnological uses.
