Yanick Crow

Yanick Crow is a Physician Scientist at the Institute of Genetics and Cancer, University of Edinburgh. His research focuses on genetic disorders affecting human neurological and immune function, particularly Aicardi-Goutières syndrome (AGS) and type I interferonopathies, as well as leukoencephalopathy with calcifications and cysts (LCC) and Coats plus (CP). He leads a multidisciplinary team integrating clinical, genetic, and immunological approaches.

Research Interests: Dr. Crow’s group explores the molecular mechanisms underlying

• Type I interferon upregulation in autoinflammatory/autoimmune diseases
• Genetic basis of rare brain calcification disorders
• Therapeutic development for interferonopathies (e.g., JAK inhibitors)
• Development of zebrafish models for LCC
• Shared disease mechanisms in genetically distinct neuro-radiological syndromes
• Immunological implications for systemic lupus erythematosus

Collaborations: His team collaborates with institutions including University of Manchester, Institut Pasteur (Paris), and University of Oxford.

Grants and Funding: Research is supported by the Medical Research Council (MRC), European Research Council (ERC), and LifeArc.

Labs and Teams: The group includes

• Post-doctoral researchers: Carolina Uggenti, Marie-Therese El-Daher, Andrew Badrock
• PhD students: Callie Wong, Gaofeng Zhu
• Technicians and assistants: Eve White, Fraser Sutherland

and utilizes zebrafish models for mechanistic studies.