Yan Xu

Yan Xu is a Research Professor at NJIT's Center for Solar-Terrestrial Research, specializing in nanomedicine and advanced drug delivery systems. His research develops innovative nanoparticle platforms for mRNA therapeutics, siRNA delivery, and targeted cancer treatments.

Research focuses on nanoscale delivery systems including lipid nanoparticles, polymer hybrids, and protein-based carriers for applications in oncology (brain tumors, lung cancer), metabolic disorders (steatohepatitis, fibrosis), and vaccine development. Therapeutic strategies encompass mRNA-mediated antibody therapy, STING agonist delivery, and RNA interference techniques.

Recent publications demonstrate advancements in inhalable formulations for pulmonary diseases, tumor-targeting systems for immunotherapy potentiation, blood-brain barrier penetration methods, and lyophilizable vaccine platforms. Article themes consistently integrate nanotechnology with therapeutic payloads across diverse disease models.

Key innovations include enzyme-catalyzed lipid synthesis for COVID-19 vaccines, 'Particle-in-Particle' nanostructures, H-ferritin nanoparticles for brain delivery, and hydrogels for vascular tissue engineering.