Xue Han

Xue Han is a Professor of Biomedical Engineering at Boston University (BU), affiliated with the Han Lab. His primary academic appointment is in the Biomedical Engineering department, with additional affiliations in Neuroscience & Neuroengineering, and Photonics & Optical Systems. He holds a PhD in Physiology from the University of Wisconsin-Madison and a B.S. in Biophysics from Beijing University, China.

Dr. Han’s research focuses on addressing unmet medical needs in brain disorders by developing novel neuromodulation therapies. His work combines genetic, molecular, pharmacological, optical, and electrical tools to study neural circuit dynamics, with a particular emphasis on optogenetics and optical neural modulation. Key projects include pioneering light-based neuron silencing techniques and pre-clinical testing of neurotechnologies like transcranial ultrasound stimulation. His lab investigates how neural synchrony contributes to cognition and pathology, aiming to link neural activity to behaviors like movement, attention, and decision-making.

His recent publications emphasize high-frequency electrical stimulation effects, membrane voltage imaging, and the impact of neuromodulation on brain rhythms. Notable themes include the role of PV neurons in cortical coding, ultrasound-based neuron activation, and the interplay between neural oscillations and disease states. While no formal awards are listed, his prolific output highlights contributions to neurotechnology and systems neuroscience.

Dr. Han’s lab develops advanced imaging tools like targeted-illumination confocal microscopy (TICO) and collaborates on projects involving exosome-mediated therapies and brain-computer interfaces. Ongoing work explores translational applications of neurophotonic tools and the mechanistic basis of neuromodulation therapies for disorders like Parkinson’s and epilepsy.