Xinbo Yang

Xinbo Yang, PhD, is an Assistant Professor at Memorial Sloan Kettering Cancer Center (MSKCC), affiliated with the Molecular Pharmacology Program and Gerstner Sloan Kettering Graduate School of Biomedical Sciences. His lab focuses on decoding T cell receptor (TCR) specificity in cancer and autoimmune diseases using interdisciplinary approaches like structural biology, protein engineering, and antigen-discovery platforms. Key research areas include understanding self-foreign discrimination mechanisms and developing pMHC-based therapies.

Dr. Yang holds a PhD from the University of Maryland, College Park. His work addresses TCR misrecognition in autoimmune conditions and therapeutic strategies for cancer immunotherapy. Notable projects include engineering TCRs with tailored sensitivity and identifying antigens for orphan TCRs to improve therapeutic targeting.

Publications highlight advancements in antibody repurposing for cancer, HLA-B27-associated autoimmunity mechanisms, and T cell-based therapies for leukemia. Collaborations span structural biology, immunology, and oncology, with a focus on translational applications. Disclosure includes equity in 3T Biosciences, reflecting industry engagement in biotechnology.