Warren S. Pear

Warren S. Pear is the Gaylord P. and Mary Louise Harnwell Professor at the University of Pennsylvania, with affiliations including the Abramson Cancer Center, Abramson Family Cancer Research Institute, and Institute for Immunology. He serves as Director of the Immunopathology Division, Vice Chair of Research in the Department of Pathology & Lab Medicine, and Deputy Director of the Institute of Immunology.

• Education
  • B.A. in Economics from Williams College (1980)
  • Ph.D. in Tumor Biology from Karolinska Institute (1987)
  • M.D. from University of Rochester (1989)

Dr. Pear's research focuses on the molecular mechanisms of Notch signaling and Tribbles in hematopoiesis and leukemia, using in vivo/in vitro models, gene array analysis, and CRISPR technology. His work bridges tumor biology, stem cell research, and immunobiology.

His recent publications highlight studies on T cell exhaustion, epigenetic drug resistance, and Notch-regulated cell fate decisions. Collaborators include Dr. Babak Faryabi and Dr. Martha Jordan, with whom he explores transcriptional pathways and immune regulation.

Labs & Teams: Leads the Pear Lab, which investigates Notch and Tribbles in cancer and immunity, training PhD students and postdoctoral researchers in molecular pathology and immunobiology.