W. Jonathan Lederer

W. Jonathan Lederer is a Professor of Physiology at the University of Maryland School of Medicine and Director of the Center for Biomedical Engineering and Technology. He holds additional affiliations as an Adjunct Professor at the University of Vermont, Guest Professor at the University Medical Center Göttingen, and Adjunct Research Scientist at Johns Hopkins University. His research focuses on calcium signaling, excitation-contraction coupling, and X-ROS signaling in cardiac and muscle physiology.

His laboratory pioneered the discovery of calcium sparks (1993) and X-ROS signaling (2011), linking calcium dynamics to arrhythmogenesis, heart failure, and mechano-chemical transduction. He has advanced confocal and super-resolution imaging techniques to study subcellular calcium events in real-time.

Dr. Lederer’s recent publications emphasize calcium sparks, X-ROS signaling, and calcium-mitochondria interactions, with computational modeling of high-resolution calcium dynamics. His work spans collaborations in physiology, biophysics, and cardiovascular disease research.

Scientific Awards:

• British Heart Foundation - American Heart Association Fellowship (1977-1979)
• NIH Merit Award (1993-2003)
• Cole Award, Biophysical Society (1998)
• Peter Harris Distinguished Scientist Award (2015)

Current Appointments:

• Professor of Physiology, University of Maryland School of Medicine (1988-present)
• Guest Professor, Department of Cardiology, Göttingen (2009-present)
• Adjunct Research Scientist, Johns Hopkins (2010-present)