Valentin Stein

Prof. Dr. Valentin Stein leads research at the Institute of Physiology II, University of Bonn, focusing on synaptic mechanisms underlying brain function and neurodevelopmental disorders. His team investigates protein interactions at glutamatergic synapses, particularly AMPA receptor regulation through posttranslational modifications like neddylation.

Key research areas include: 1) Molecular basis of synaptic plasticity and spine dynamics; 2) Neddylation's role in synaptic transmission/cognition; 3) Neurophysiological impacts of stress vulnerability; 4) Ion channel dysfunction in epilepsy. Experimental approaches combine electrophysiology, molecular biology, and in vivo two-photon microscopy.

Publications demonstrate translational neuroscience linking fundamental synaptic processes to cognitive outcomes, with implications for epilepsy, neurodegenerative diseases, and neuropsychiatric conditions.