Tom Muir

Tom Muir is the Van Zandt Williams Jr. Class of 1965 Professor of Chemistry at Princeton University, leading the Muir Lab. His research integrates organic chemistry, biochemistry, and cell biology to study protein function in complex biomedical systems. The lab develops chemical tools to manipulate proteins, with a focus on chromatin structure, histone modifications, and bacterial communication pathways. Key projects include designer chromatin systems, oncohistone mechanisms, and intein-based protein engineering.

Research Interests:
- Chromatin dynamics and epigenetic regulation
- Oncohistones and cancer-associated histone mutations
- Protein engineering via inteins and transamidation
- Staphylococcus aureus virulence pathways
- Development of chemical biology tools for biomedical research

• Recipient of major honors including Royal Society Fellowship (2021), American Academy of Arts and Sciences (2020), and multiple ACS awards.
• Lab website: muir.princeton.edu