Tom Luk R Michoel

Tom Luk R Michoel is a Professor at the Computational Biology Unit within the Department of Informatics at the University of Bergen. His research focuses on bioinformatics, computational biology, and machine learning applied to understanding gene regulation and causal relationships in biological systems. He teaches in both the Bachelor and Master programs in Informatics, including courses like BINF301 and MNF130.

Research Interests: Michoel’s work explores how genetic variation influences gene expression and disease mechanisms. He develops machine learning algorithms to infer causal gene regulatory networks from large-scale genomic data, emphasizing causal inference over mere correlations. His recent projects include analyzing plasma protein networks linked to cardiovascular disease and applying Bayesian networks to understand gene-disease associations.

Publications: His most recent work (2025) focuses on causal protein networks in myocardial infarction risk and network-driven frameworks for coronary artery disease studies. He also contributes to methodological advancements like integrating graph neural networks with metabolic models.

Current Activities: Michoel leads the development of tools like Findr.jl for network inference and teaches short courses on causal inference in drug discovery. His lab collaborates on projects involving single-cell analysis, multi-tissue genomics, and systems pharmacology.