Todd D. Gould

Todd D. Gould is a Professor in the Department of Psychiatry at the University of Maryland, Baltimore School of Medicine, with secondary appointments in Neurobiology and Pharmacology. His research laboratory investigates the pathophysiology of mood disorders and mechanisms of psychiatric drug actions using multidisciplinary approaches.

His educational background includes:

• MD from the University of Virginia
• Fellowship at the National Institute of Mental Health (NIMH) Laboratory of Molecular Pathophysiology and Experimental Therapeutics, focusing on lithium's mood-stabilizing mechanisms

Research centers on depression, bipolar disorder, and pharmacology of ketamine, hydroxynorketamine, and lithium. The lab develops improved animal models for psychiatry and studies mood disorder susceptibility genes like Cacna1c, aiming to enable earlier interventions and novel treatments through translational neuroscience.

Recent publications emphasize ketamine's NMDAR-independent antidepressant mechanisms, Cacna1c's role in social stress susceptibility, and dopamine system alterations in mood disorders. Work bridges molecular neuroscience with clinical applications to develop rapid-acting treatments without ketamine's side effects.

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Information about students advised and research grants was not provided in the source material.

Dr. Gould leads the Gould Lab, which employs genetic, pharmacological, biochemical, electroencephalographic, and behavioral methods to advance mood disorder research. The lab collaborates with clinical researchers and maintains active projects detailed at www.gouldlab.org.