Ting-Yu Lin

Ting-Yu Lin is an Assistant Professor in Structural Biology at Durham University. Her research investigates RNA modification enzymes using biochemical and cryo-EM approaches, focusing on pseudouridine synthases linked to neurological disorders.

Research includes:

• Structural analysis of tRNA-modifying enzymes
• Mechanistic studies of pseudouridylation
• Pathogenic mutation characterization
• Cryo-EM of macromolecular complexes
• Enzyme-substrate specificity

Her work connects enzyme dysfunction to intellectual disability pathologies through biochemical and cell-based assays.