Timothy R Zacharewski

Timothy R Zacharewski is a Professor at the Department of Biochemistry & Molecular Biology at Michigan State University, affiliated with the Genetics & Genome Sciences Program and Cell & Molecular Biology Program. His research focuses on nuclear receptor-mediated toxicity, particularly how environmental chemicals, drugs, and natural products affect gene expression in the liver and endocrine system.

• Ph.D. (1990) - Texas A&M University
• B.S. (1986) - University of Guelph

Using in vivo rodent and in vitro cell line models, he compares human, mouse, and rat responses to reduce cross-species extrapolation uncertainties. His work integrates toxicology, genomics, and computational approaches to study mechanisms like coagulation-driven fibrosis, pyruvate kinase isoform switching, and circadian rhythm disruption linked to TCDD exposure.

Recent publications highlight aryl hydrocarbon receptor pathways, metabolic reprogramming, and cross-species gene expression comparisons in mouse models. The lab employs bioinformatics and multi-omics analyses (lipidomics, transcriptomics) to explore environmental contaminant impacts on bile acid homeostasis, antibiotic resistance gene reservoirs, and REV-ERBα/β activation in hepatotoxicity.

Professor Zacharewski's research has significant implications for understanding human risk from xenobiotic exposures and improving toxicity modeling frameworks.