Timothee Lionnet

Timothee Lionnet is an Associate Professor in the Department of Cell Biology at NYU Grossman School of Medicine. He holds a PhD from the University of Paris and completed postdoctoral training at Albert Einstein College of Medicine in Robert H Singer's lab. His research focuses on understanding how cells regulate gene expression through single-molecule imaging, bridging molecular-scale observations with cellular and tissue-level processes.

• Education: PhD in Paris, Postdoc at Einstein College of Medicine

His work integrates live-cell imaging technologies, computational modeling, and systems genetics to investigate transcriptional dynamics, epigenetic regulation, and cellular responses to environmental cues. The Lionnet Lab develops novel tools to visualize gene activity in real time, aiming to uncover principles of robust gene expression programs and their role in diseases like cancer and viral reactivation.

Recent research highlights include studies on chromatin landscape evolution in acute lymphoblastic leukemia, transcriptional stochasticity, and therapeutic resistance mechanisms in cancer cells. The lab collaborates on projects involving zinc finger design for genome editing and systems-level analysis of melanoma genetics.

Lab activities emphasize interdisciplinary approaches, combining quantitative biology with clinical insights to advance regenerative medicine and cancer therapy strategies.