About
Dr. Tim Blackburn is a researcher at Newcastle University, with a focus on medicinal chemistry, biochemistry, and synthetic organic chemistry. His work primarily targets cancer research through the development of protein-protein interaction inhibitors and kinase inhibitors, alongside synthetic methods for complex natural products like phomactins.
Key research themes include:
- Designing ERK5 and MDM2-p53 inhibitors for cancer therapy
- Advancing synthetic approaches for phomactins and isoindolinone derivatives
- Optimizing pharmacokinetics and potency in drug candidates
His peer-reviewed publications (2006–2022) reflect expertise in:
- Medicinal Chemistry (MDM2-p53 inhibition, GABA A agonists)
- Organic Synthesis (stereoselective Wittig rearrangements, oxidation methods)
- Cancer Pharmacology (Tip60 inhibitors, ERK5 inhibition)
- Kinase Inhibition (ERK5, p38α selectivity)
- Chemical Biology (protein-protein interactions, epigenetics)
- Drug Development (oral bioavailability, structure-activity studies)
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