Tianxin Yang

Tianxin Yang is a Professor of Nephrology & Hypertension and Adjunct Professor of Nutrition and Integrative Physiology at the University of Utah School of Medicine. His research focuses on hypertension, kidney disease, and metabolic disorders with an emphasis on (pro)renin receptor signaling, lipid mediators, and distal nephron function.

• Ph.D., Tokyo Medical and Dental University

Yang's work has defined the role of the COX-2/mPGES-1/PGE2 pathway and PPAR gamma in renal health, and his recent studies demonstrate PRR's critical role in urinary Na⁺ and water excretion. Overactivation of PRR contributes to hypertension and chronic kidney disease via enhanced intrarenal RAS and ENaC expression.

Analysis of Yang's 15 most recent articles reveals trends in renal physiology, hypertension mechanisms, and translational approaches to metabolic syndrome. Key sub-fields include PRR cleavage, ENaC regulation, vasopressin signaling, oxidative stress, lipid-nephron interaction, and therapeutic targeting of RAS.

Yang's laboratory employs

• Conditional gene targeting
• Radiotelemetry
• Cell culture
• Mouse renal physiology
• Drug library screening

to develop novel treatments for kidney and cardiovascular diseases.