Thorsten Schinke

Thorsten Schinke is a full-time faculty member and Professor at the Department of Osteology and Biomechanics, University of Hamburg-Eppendorf (UKE). His research focuses on molecular mechanisms of bone remodeling, Wnt/Notch signaling, osteoimmunology, and genetic factors in skeletal disorders.

• Key Research Themes: Wnt Signaling, Osteoporosis, Osteoimmunology, Skeletal Metastasis, Genetic Bone Diseases, Osteal Macrophages

Scientific Contributions: Schinke has led 8 DFG-funded projects (2010-2021) exploring interactions between bone remodeling and disease states. His work includes identifying novel roles for Rsk2, PLS3, and Notch2 in osteosarcoma progression, X-linked osteoporosis, and Hajdu-Cheney syndrome. Using genetically engineered mouse models, he established connections between cytokine signaling (e.g., IL17, S1P), lysosomal dysfunction, and skeletal pathology.

Recent Trends: Analysis of 15 recent publications (2017-2021) reveals expertise in in vivo bone modeling, histomorphometry, and cross-disciplinary approaches combining immunology and bone biology. Key subfields include tumor-bone interactions, Wnt-stimulated anabolism, and metabolic regulation of osteoblast/osteoclast balance.

• Scientific Awards:
  • DFG Project 401122336 (2018-2021)
  • DFG Project 385501541 (2017-2021)
  • DFG Project 278045702 (2015-2019)
  • DFG Project 235869912 (2013-2017)
  • DFG Project 27463524 (2010-2014)

Contact: Research conducted at Campus Lehre N55, Martinistrasse 52, Hamburg. Email: fis@uke.de