Thomas P Davis

Thomas P Davis is a Professor at the University of Arizona, affiliated with the BIO5 Institute, the Department of Pharmacology, and Neuroscience-related Graduate Interdisciplinary Programs (GIDPs). His research focuses on the blood-brain barrier (BBB) and neurovascular unit (NVU) in health and disease, particularly examining BBB modulation in stroke, hypoxia, and acute pain conditions.

• Email: davistp@arizona.edu
• Lab Website: Arizona Brain Barriers Laboratory

Dr. Davis's work has pioneered the discovery of signaling pathways and transporters (e.g., OATP1a4, P-gp) that regulate BBB permeability for CNS drug delivery. Key contributions include demonstrating oxidative stress-induced BBB disruption reversed by Tempol, and altered transporter dynamics during inflammatory pain and stroke.

Recent publications highlight BBB transporter regulation in ischemic stroke, CNS homeostasis under hypoxia, and functional implications of tight junction protein modulation. His research also explores non-prescription drug interactions (e.g., acetaminophen) with BBB transporters.

• Scientific Recognition
  • Founder of the award-winning BBB drug delivery program at the University of Arizona (active since 1980)