Thomas Miller

Thomas Miller is an Associate Professor in the Department of Cellular and Molecular Medicine at the University of Copenhagen, working within the Molecular Aging Program. His research focuses on understanding the molecular mechanisms that maintain eukaryotic genome stability during DNA replication using genetic, biochemical, cellular, and structural techniques, including cryo-EM.

Dr. Miller's primary research interests include:

• Molecular mechanisms of faithful genome replication
• How failures in genome stability maintenance cause developmental disorders and age-related diseases
• The role of replisomes and accessory factors in regulating chromosome replication

His current research projects specifically investigate:

• The mechanisms and regulation of MCM helicase loading
• Replication-coupled DNA-protein crosslink (DPC) repair
• Accessory helicases in DNA replication
• Electron microscopy methods development through 'Reconstitution in silico' (RECONSIL)

Dr. Miller's publication record demonstrates expertise across structural biology, molecular mechanisms of DNA replication, and cryo-EM techniques. His recent work spans from fundamental studies of replisome structure and function to developing new methodologies for studying DNA replication processes. His research has significant implications for understanding developmental disorders and age-related diseases including neurodegeneration and cancer.

Dr. Miller is the founder of TCRM Consulting, indicating industry engagement alongside his academic work.