Thomas Köglsperger

Thomas Köglsperger is a Clinical Associate Professor and Research Group Leader at the Department of Neurology, LMU Klinikum, Ludwig Maximilian University of Munich, with dual affiliation at the German Center for Neurodegenerative Diseases (DZNE). His work bridges clinical neurology and molecular neuroscience to advance therapeutic strategies for movement disorders, particularly Parkinson's disease.

His research program integrates two core domains: (1) Clinical investigation of Deep Brain Stimulation (DBS) programming for Parkinson's disease, tremor, and dystonia; and (2) Experimental dissection of Parkinson's molecular mechanisms using patch-clamp electrophysiology, biochemical assays, and advanced imaging. Key initiatives include characterizing Fragile X Mental Retardation Protein (FMRP) depletion in Parkinson's pathology, identifying gastrointestinal miRNA biomarkers, and elucidating extracellular vesicle roles in neurodegeneration. These efforts reflect a strategic focus on translating molecular insights into clinical applications.

Analysis of his 2013-2020 publications reveals a cohesive trajectory prioritizing Parkinson's disease across biological scales—from TGF-β-mediated microglial signatures and exosome dynamics to evidence-based DBS protocols. Recurring themes include protein dysregulation (FMRP, α-synuclein), neuromodulation optimization, and multi-compartment biomarker discovery, demonstrating consistent integration of basic science with patient-centered neurology.

Scientific Awards: No awards or fellowships were documented in available sources.

Advising and Grants: Source materials provided no details regarding doctoral students, postdoctoral trainees, or funded research projects.

Dr. Köglsperger directs an independent research group within LMU Klinikum's Department of Neurology, maintaining active collaboration with DZNE to drive translational neuroscience in movement disorders through combined clinical-experimental approaches.