Thomas Frosio

Thomas Frosio is a Researcher at the electron Bio-Imaging Centre (eBIC) at Diamond Light Source, where he joined in March 2025. His expertise centers on advancing cryo-electron tomography (cryoET) methodologies for high-resolution biological imaging.

Education:

• DPhil in Structural Biology, University of Oxford, completed in Peijun Zhang's laboratory at eBIC

Research Focus: Thomas specializes in computational aspects of cryoET, developing algorithms for motion-correction to mitigate sample drift, precise tilt-series alignment for 3D reconstruction, and CTF estimation to correct electron microscope distortions. His work bridges structural biology and computational imaging, enabling atomic-level visualization of cellular machinery.

Professional Context: As part of Diamond Light Source's eBIC team, he contributes to the UK's national synchrotron facility at Harwell Campus, supporting cutting-edge research in life sciences through advanced bio-imaging infrastructure and expertise.