Tatiana Goretsky

Tatiana Goretsky, PhD, is an Assistant Professor in the Department of Internal Medicine at the University of Kentucky College of Medicine, with a focus on Digestive Health and Nutrition. Her research is centered on the molecular mechanisms underlying inflammatory bowel disease (IBD), epithelial cell signaling, and mucosal repair.

Education:

• Masters in Physiology of Animals and Humans, Lomonosov State University, Moscow, Russia
• PhD in Biochemistry, Russian Academy of Sciences, Pushchino, Moscow Region, Russia

Her research interests span Inflammatory Bowel Disease, β-catenin and NF-kappaB signaling, mitochondrial function in the gut, and epithelial cell apoptosis and regeneration. Her work integrates molecular biology, cell signaling, and translational gastroenterology to understand disease pathogenesis and identify therapeutic targets.

Analysis of her recent publications reveals a strong focus on signaling pathways such as PI3K, β-catenin, and TNF in the context of intestinal injury, repair, and cancer. Her studies frequently explore how dysregulation of these pathways contributes to IBD and colitis-associated neoplasia, with emerging work on mitochondrial metabolism and microbiome interactions.

Scientific Contributions:

• Investigated β-catenin cleavage and activation in colitis
• Elucidated roles of p53 and PHLPP in epithelial apoptosis
• Demonstrated TNF receptor signaling in mucosal repair
• Explored mitochondrial function in IBD pathogenesis
• Examined PI3K signaling in radiation-induced gut injury

Dr. Goretsky actively collaborates with Dr. Terrence A. Barrett and other researchers in gastrointestinal pathobiology. While no formal advisees are listed, her publications suggest mentorship roles in collaborative research. She has no publicly listed scientific awards in the provided text. Her lab likely focuses on epithelial signaling mechanisms in digestive diseases, contributing to the broader mission of the Digestive Health and Nutrition division at UK.