Susanne Bornelöv

Susanne Bornelöv is a Professor in the Department of Biochemistry at the University of Cambridge. Her research focuses on computational genomics and gene regulation, particularly exploring posttranscriptional mechanisms such as codon optimality-mediated mRNA decay and transposon silencing. She uses computational methods, ribosome profiling, and Drosophila models to study how codon usage, tRNA availability, and RNA modifications influence gene regulation and genome evolution.

Her work integrates artificial intelligence (AI) and comparative genomics to model gene regulatory processes and design novel regulatory elements. Key research areas include piRNA clusters' roles in suppressing retroviruses, codon usage bias in pluripotent stem cells, and the interplay between mRNA methylation and protein synthesis. The Bornelöv Group collaborates widely, including with institutions like Cold Spring Harbor Laboratory, to advance understanding of fundamental gene expression principles.

Publications highlight contributions to topics like deep learning in genomics, evolutionary conserved piRNA mechanisms, and transcriptional regulation. She leads a group open to interns, students, and researchers, fostering interdisciplinary approaches to address complex biological questions.