Stuart M. Weston

Stuart M. Weston is a Research Associate in the Department of Microbiology and Immunology at the University of Maryland School of Medicine. His research focuses on virus-host interactions and the development of broad-spectrum antiviral drugs targeting pandemic pathogens such as coronaviruses and influenza viruses.

His educational background includes:

• B.Sc. in Biomedical Sciences from University College London (2009-2012)
• Ph.D. from the MRC Laboratory for Molecular Cell Biology, University College London (2012-2016)
• Post-doctoral fellowship at the University of Maryland School of Medicine in the lab of Matthew Frieman (2016-2021)

Weston's research centers on virus-host interactions to develop broad-spectrum antivirals. He addresses the limitations of current antivirals (viral resistance and narrow spectrum) by targeting host factors. His key contribution is identifying the SKI complex, a host protein complex, as a target for antivirals effective against coronaviruses, influenza, and filoviruses. Using yeast-based screening, his lab discovers host factors and develops antiviral compounds. This host-directed approach promises drugs less prone to resistance and with broader applicability, crucial for pandemic preparedness against emerging respiratory viruses.

His recent publications (2019-2021) demonstrate concentrated coronavirus research, particularly SARS-CoV-2, extending to influenza and filoviruses. Key themes include drug repurposing, host factor identification (like SIRT1 and the SKI complex), and vaccine development. The work combines high-throughput screening, molecular virology, and in vivo models to advance broad-spectrum antiviral strategies.

No scientific awards are mentioned. He has not listed any students or advisees. His research is conducted within the laboratory of Dr. Matthew Frieman, focusing on emerging viral pathogens and antiviral drug discovery.