Steven Kerfoot

Steven Kerfoot is an Associate Professor at Western University, focusing on B cell immune responses in inflammatory and autoimmune diseases. His research explores how B cells contribute to protective immunity versus pathological inflammation, particularly in multiple sclerosis and chronic inflammatory conditions. He holds a PhD from the University of Calgary and completed a postdoctoral fellowship at Yale University School of Medicine. His lab, located at Health Sciences Addition 312, investigates mechanisms underlying autoimmune pathology, B-T cell interactions, and therapeutic interventions.

Research Interests: Central to his work are B and T cell dynamics, germinal center responses, and their role in diseases like multiple sclerosis. His lab uses experimental models and human translational approaches to dissect immune mechanisms. Key projects include studying B cell plasticity, antigen presentation pathways, and the role of macrophages in cancer initiation driven by chronic inflammation.

Publications highlight advancements in understanding B cell subsets, anti-CD20 therapy mechanisms, and the impact of microbiota on MS treatment. His work bridges basic immunology with clinical applications, including pilot trials on fecal microbiota transplantation for MS.

Awards: No formal awards listed, though his contributions are reflected in his robust publication record and active research programs. His lab collaborates widely, focusing on translational immunology and inflammatory disease modeling.

Lab: Visit kerfootlab.com for ongoing projects, including the MOGtag protein antigen platform and insights into autoimmune disease mechanisms.