Steve Mayo

Steve Mayo serves as the Bren Professor of Biology and Chemistry and Merkin Institute Professor at the California Institute of Technology (Caltech), leading the Mayo Laboratory focused on advancing computational protein design methodologies.

His research integrates theoretical, computational, and experimental structural biology approaches to pioneer quantitative protein design strategies, specifically developing the concept of "protein design automation." The laboratory's software suite—including ORBIT (Optimization of Rotamers By Iterative Techniques) and TRIAD—enables systematic solutions for protein fold stabilization, enzyme design, antibody engineering, and de novo enzyme creation, significantly impacting synthetic biology and therapeutic development.