Stephen Eyre

Stephen Eyre is a Professor and Chair at the Division of Musculoskeletal & Dermatological Sciences, University of Manchester. His research focuses on the genetic and genomic basis of rheumatological disorders, particularly inflammatory and autoimmune joint diseases like rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA).

• Arthritis Research UK Centre of Excellence (since 1996)
• Collaborator with institutions: Harvard Medical School, Babraham Institute, University of Cambridge, UCL

Research interests include:

• Elucidating mechanisms of arthritis-associated DNA variants via Capture HiC and CRISPR-Cas9
• Investigating immunological, epigenetic, and non-coding RNA consequences of RA loci
• Multi-omics approaches in primary T cells and synovial tissue

Recent publications highlight trends in:

• Functional genomics for causal gene discovery in autoimmune diseases
• Transcriptome imputation models across populations
• Mechanistic links between genetic loci and immune dysfunction

Collaborations span:

• Professor Soumya Raychaudhuri (Harvard Medical School)
• Dr Peter Fraser (Babraham Institute)
• Professor David Sansom (UCL)

Supervised researchers include Dr Annie Yarwood, Dr Amanda McGovern, and others. His work contributes to the Lydia Becker Institute and aligns with UN Sustainable Development Goals for health equity.