Simon Wing

Simon Wing is a Senior Scientist at the RI-MUHC (Glen site) and Professor in the Department of Medicine, Faculty of Medicine and Health Sciences at McGill University. He leads the Metabolic Disorders and Complications Program within the Centre for Translational Biology.

• MD from McGill University
• Residency in Internal Medicine & Endocrinology/Metabolism
• Postdoctoral training with Alfred Goldberg (Harvard), Denis Banville, and David Thomas (NRC Canada)
• Established lab at McGill's Polypeptide Group

Research Focus: The Wing lab investigates ubiquitin-proteasome system in disease contexts, including:

• Neurodegeneration: Parkinson's disease, α-synuclein ubiquitination, Lewy body formation
• Reproductive Biology: Spermatogenesis regulation by ubiquitin ligases (HUWE1), fertility mechanisms
• Metabolic Disorders: Diabetes, obesity, glucose intolerance in USP19 knockout mice
• Muscle Biology: Cachexia, atrophy, and differentiation via USP19 and deubiquitinating enzymes

Publication Trends: Recent work emphasizes neurodegenerative disease mechanisms, metabolic syndrome links, and ubiquitin system regulation. Key collaborations include Canadian Longitudinal Study on Aging and McGill University Health Centre clinical research.

Laboratory Team: Maintains a multidisciplinary team with expertise in in vivo mouse models, ubiquitin biochemistry, and cellular imaging. Notable alumni include Hung-Hsiang Ho (Parkinson's imaging), Erin Coyne (muscle atrophy), and Rohini Bose (spermatogenesis).