Simon Baker

Dr. Simon Baker is a Kidney Research UK Intermediate Fellow at the Jack Birch Unit for Molecular Carcinogenesis within the Department of Biology at the University of York. His research focuses on genomic and transcriptomic methods to study DNA damage and mutational signatures in bladder cancer. He investigates how BK polyomavirus induces APOBEC-mediated genomic damage, linking viral infections to cancer etiology. His work combines experimental models, clinical data, and public involvement to improve bladder cancer diagnosis and treatment strategies.

Research Interests: Dr. Baker’s primary focus is on understanding the molecular mechanisms underlying bladder cancer initiation, particularly the role of mutational signatures and viral infections. His studies explore APOBEC enzymes’ contributions to genomic instability, viral oncogenesis pathways, and the interplay between environmental toxins and genetic mutations. He also develops in vitro models to simulate carcinogenesis processes and validate therapeutic targets.

Scientific Contributions: His publications emphasize mutational signature analysis, BKPyV pathogenesis, and clinical surveillance strategies for bladder cancer. The most recent articles highlight advancements in linking viral infections to cancer through APOBEC activation and refining patient care protocols.

Awards and Recognition: He holds the prestigious Kidney Research UK Intermediate Fellowship, supporting his exploration of BKPyV as a bladder cancer driver. His research integrates clinical relevance with basic science, aiming to translate findings into improved patient outcomes.

Teaching and Outreach: Dr. Baker leads educational initiatives through York Against Cancer’s Enthuse partnership, enhancing cancer education in secondary schools. He supervises students across undergraduate, master’s, and doctoral programs, fostering the next generation of biomedical researchers.