Sim Tiow Suan

Associate Professor Sim Tiow Suan is an Associate Professor in the Department of Microbiology and Immunology at the Yong Loo Lin School of Medicine, National University of Singapore (NUS), where she also serves as Assistant Dean (Research). Her work bridges malaria parasitology, antibiotic biotechnology, and environmental water quality assessment.

She holds a BSc (Hons) and PhD, though specific institutions are not detailed in the source material.

Professor Sim's research program focuses on three interconnected domains:

• Anti-malarial drug discovery: Molecular characterization of Plasmodium falciparum targets including Hsp90 co-chaperones, cysteine proteases, and atypical kinases to develop novel therapeutics against drug-resistant malaria.
• Enzyme engineering: Rational mutagenesis of deacetoxycephalosporin C synthase (DAOCS) to enhance cephalosporin production and substrate versatility for industrial antibiotic synthesis.
• Environmental microbiology: Development of comprehensive testing batteries for water quality monitoring, integrating bacteriological assays, coliphage evaluation, parasite detection, and PCR-based species identification.

Her publication record (2009-2014) reveals deep specialization in malaria parasite molecular mechanisms, particularly Hsp90 regulatory networks and kinase pathways, alongside significant contributions to industrial enzyme engineering. The work consistently employs integrated approaches combining in silico modeling, site-directed mutagenesis, and biochemical validation across parasitology and biotechnology domains.

No scientific awards were explicitly referenced in the source documentation.

As research leader and Assistant Dean, she oversees laboratory operations and institutional research strategy, though specific grant awards or student supervision details remain undocumented in the provided materials.

Her laboratory maintains active programs in parasite molecular biology and enzyme biotechnology, utilizing structural analysis and genetic engineering to address therapeutic and environmental challenges.