Silvia Arber

Silvia Arber holds a joint appointment as Full Professor for Neurobiology/Cell Biology at the Biozentrum, University of Basel, and serves as Senior Group Leader at the Friedrich Miescher Institute (FMI) in Basel, Switzerland. Her laboratory investigates the organization, function, and development of neuronal circuits controlling motor behavior, with a particular focus on how these circuits enable precise movement control.

Arber obtained her PhD in 1996 from the Friedrich Miescher Institute under Pico Caroni, followed by postdoctoral training with Thomas Jessell at Columbia University (1996-2000), where she studied transcription factors in spinal cord neuronal differentiation. Her educational background includes Biology II studies at the Biozentrum of the University of Basel with graduation in Cell Biology (1987), a diploma thesis at the FMI (1990), and graduate work at the FMI (1992).

Her research program centers on elucidating how neuronal circuits orchestrate accurate motor behavior in response to sensory cues and voluntary movement initiation. Using mouse as a model system, her laboratory employs multi-faceted approaches including advanced mouse genetics, viral technologies for transsynaptic circuit tracing, optogenetics and pharmacogenetics for functional manipulation, quantitative behavioral analysis, electrophysiology, and gene expression profiling. Her work has revealed precise synaptic interactions within dedicated motor circuit modules throughout the nervous system and how these impact function, with implications for understanding diseases causing motor deficits and spinal cord injury.

Analysis of Arber's publication record shows a consistent focus on motor circuit organization, with particular emphasis on transcriptional control mechanisms, circuit connectivity mapping, and the relationship between developmental processes and functional circuit organization. Her work bridges molecular, cellular, and systems neuroscience, providing fundamental insights into how the nervous system controls movement.

• The Brain Prize (2022)
• Elected to the National Academy of Sciences of the United States (2020)
• Physiological Society Annual Review Prize Lecture (2019)
• Pradel Research Award (2018)
• W. Alden Spencer Award (2018)
• Louis-Jeantet Prize for Medicine (2017)
• ERC Advanced Grant (2010-2015)
• EMBO Member (2005)
• EMBO Young Investigator Award (2001)

While specific students are not listed in the provided materials, Arber's laboratory has received significant research funding including an ERC Advanced Grant (2010-2015) and multiple prestigious awards supporting her research program. Her laboratory at the Biozentrum (Room 11.038) collaborates closely with the Friedrich Miescher Institute, where she serves as Senior Group Leader. The research group employs cutting-edge technologies for neural circuit analysis and has contributed fundamental insights into motor circuit organization, with implications for understanding and potentially treating movement disorders and spinal cord injuries.