About
Dr. Si Ming Man is a CSL Centenary Fellow and NHMRC Leadership Fellow at the John Curtin School of Medical Research (Australian National University). With a PhD from the University of Cambridge and postdoctoral training at St. Jude Children’s Research Hospital, he leads research on innate immunity in host defense against infectious diseases and cancer. His work focuses on inflammasomes, pattern-recognition receptors, and immune signaling pathways.
- Education:
- BMedSc (University Medal), UNSW Sydney
- PhD, University of Cambridge
- Fellow, Australian Society for Microbiology (FASM)
- Fellow, Royal Society of NSW (FRSN)
- Research Interests:
- Mechanisms of inflammasome activation by pathogens (Salmonella, Clostridium, Francisella)
- Molecular basis of inflammation in colorectal cancer and autoimmunity
- Role of guanylate-binding proteins in antimicrobial defense and tumor suppression
- Discovery of novel immune activators/inhibitors for therapeutic development
- Host-pathogen interactions in gut microbiota homeostasis
- Scientific Awards:
- Clarivate™ Highly Cited Researcher (2020–2024)
- Australian Academy of Science Gottschalk Medal (2023)
- Prime Minister's Prizes for Science Frank Fenner Prize (2022)
- ANU Vice-Chancellor's Award for Early Career Excellence (2020)
- NHMRC Research Excellence Awards (2015, 2019)
- Grants & Projects:
- NHMRC Investigator Grant Level 1 (2024)
- CSL Centenary Fellowship (2021)
- Current projects: How DNA sensing contributes to cancer development, Antimicrobial proteins in host defense, and New anti-cancer drugs for blood cancer
- Advising:
- Mentored 8 PhD students with 12 publications in journals like Nature, Science Immunology, and EMBO
- Theses cover Guanylate-binding proteins in tumorigenesis, Bacterial inflammasome activators, and DNA sensors in immunity
- Labs & Collaborations:
- Hosts a multidisciplinary lab with expertise in Western blots, organoid culture, genetic engineering, and mouse models
- Collaborations with institutions in USA, UK, and Germany
- Projects involve multidrug-resistant pathogens, cancer immunology, and vaccine development
0Publications listed
