Shigao Chen

Shigao Chen, Ph.D., serves as Professor of Radiology and Biomedical Engineering at Mayo Clinic College of Medicine. His primary appointment is in the Department of Radiology with joint appointment in the Department of Physiology & Biomedical Engineering. A leading innovator in ultrasound technology development, Dr. Chen directs a high-impact translational research program focused on quantitative disease evaluation.

His core research interests include:

• Shear wave elastography (notably Comb-push Ultrasound Shear Elastography - CUSE)
• Super-resolution microvessel imaging for vessels under 50 microns
• Liver steatosis quantification via Ultrasound Attenuation Coefficient
• Therapeutic ultrasound for targeted drug delivery

These technologies address critical clinical needs in oncology, hepatology, rheumatology, and inflammatory diseases.

Analysis of recent publications reveals dominant trends in quantitative ultrasound biomarkers, with strong emphasis on clinical validation across liver/kidney diseases and inflammatory conditions. His work consistently bridges engineering innovation with practical clinical implementation.

Professional recognition includes:

• Fellow of National Academy of Inventors (2021)
• Fellow of American Institute for Medical and Biological Engineering (2021)
• Distinguished Investigator Award (2023)
• Carman Award of Research Excellence (2022)

Dr. Chen maintains active research leadership through multiple NIH-funded projects including R01 grants from NIDDK, NIBIB, and NIAMS. His laboratory has successfully translated CUSE technology into global clinical practice through industry licensing. Current projects focus on renal microvessel imaging for chronic kidney disease and ultrasound evaluation of Crohn's disease.