Shekh Sabir

Shekh Sabir is a Research Fellow in the Medicinal Chemistry department at Monash University. His research focuses on developing novel compounds to combat bacterial infections through quorum sensing inhibition and biofilm disruption.

• 2017–2023 Research Output: 13 publications including 10 articles and 3 review papers.
• Collaborations: Active partnerships with researchers across Australia and international institutions.

Research Interests: Sabir's work primarily targets Pseudomonas aeruginosa, a major pathogen in antibiotic resistance. His research spans:

• Designing quinazolinone and dihydropyrrol-2-one analogues
• Quorum sensing inhibition mechanisms
• Biofilm disruption strategies
• Organic synthesis of antimicrobial compounds
• Addressing antibiotic resistance through alternative therapies
• Structure-activity relationship studies

Recent Publication Trends: His 2023–2025 work emphasizes:

• Cationic dihydropyrrol-2-ones as dual-action agents
• Combinations of ascorbic acid with furanones for enhanced biofilm disruption
• Disulfide-based quorum sensing inhibitors
• Halogenated compounds targeting pyocyanin biosynthesis

Technical Expertise: Sabir specializes in synthetic methodologies including Beckmann rearrangement, aziridination, and hydroxylamine reagent applications.