About
Sergio Valente is an Associate Professor in Medicinal Chemistry at the Department of Chemistry and Pharmacy Technology, Faculty of Pharmacy and Medicine, Sapienza University of Rome. His research focuses on epigenetic modulators for cancer, neurodegenerative, and parasitic diseases. He leads the Laboratory 256 dedicated to organic compound synthesis and characterization.
- Abilitations: National Scientific Abilitation (ASN, MIUR) for Associate Professor (2015)
- Education: PhD in 'Pasteur Science' (2007), cum laude degree in Pharmacy (2003)
His research develops small molecule inhibitors for HDACs, SIRTs, HMTs, KDMs, and DNMTs, targeting:
- Anticancer chemotherapy
- Neurodegenerative disorders
- Metabolic pathologies
- Antiparasitic treatments
Recent publications highlight:
- Development of SIRT5 activators for cardioprotection
- HDAC1-3 inhibitors in viral infection response
- Novel quinoline-based epigenetic modulators
- Dual-targeting strategies for LSD1/PRMT5 inhibition
- HDAC3's role in rhabdomyosarcoma radioresistance
Scientific Recognition: Recipient of the National Prize for Medicinal Chemistry Research (2017, Italian Chemical Society).
Grant Leadership: Coordinator of Ateneo 2015 Sapienza Project for LSD1 inhibitors and chemoproteomic probes.
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