Sepideh Gholami

Dr. Sepideh Gholami (M.D., M.A.S.) is a board-certified surgeon scientist with dual fellowship training in Complex General Surgical Oncology and Hepatopancreatobiliary Surgery. She serves as Director of the Liver Multidisciplinary Clinic, Hepatic Artery Infusion Pump Program, and Translational Research in Surgical Oncology at Northwell Health, while holding a joint appointment as Adjunct Associate Professor at Cold Spring Harbor Laboratory (CSHL) Cancer Center - Cancer Genetics and Genomics department.

• Education: M.A.S. from University of California Davis Medical Center, M.D. from Stanford University School of Medicine
• Certifications: American Board of Surgery (2015-2025), Fundamentals of Laparoscopic Surgery, and more

Dr. Gholami's research focuses on translational oncology and tumor microenvironment dynamics, specifically investigating:

• Development of diagnostic and prognostic biomarkers for liver cancers
• Spatiotemporal tumor-immune crosstalk in cancer progression
• Regional therapies like hepatic artery infusion for metastatic disease
• Novel therapeutics evaluation using mouse models and human organoids

Her recent publications highlight work on:

• HER2+ colorectal liver metastases treatment optimization
• Immunotherapy resistance mechanisms in microsatellite stable cancers
• KRAS mutation status in metastatic cancer treatment
• Organ-on-chip modeling for organ-specific cancer research

Scientific Awards:

• 2023 Cancer Immunotherapy Winter School Program (SITC)
• 2022 Research Fellowship (Society for Translational Oncology)
• 2021 Society of Surgical Oncology Young Investigator Award
• 2020 Southwest Oncology Group Young Investigator Award
• 2019 Cancer Pilot Grant (UC Davis)

Dr. Gholami leads the Gholami Laboratory at CSHL, specializing in translational surgical oncology and patient avatar modeling to bridge bench-to-bedside research. Her work spans clinical trial design, therapeutic innovation, and healthcare disparity analysis in gastrointestinal malignancies.