Sebas Wesseling

Sebas Wesseling serves as an Education/Research Officer specializing in Toxicology with significant contributions across 50 research publications and leadership in 8 major projects. His work bridges academic research and practical risk assessment applications in food safety and chemical toxicology.

His research focuses on critical toxicological challenges:

• Pyrrolizidine alkaloids and their N-oxides as natural toxins
• Physiologically based kinetic modeling for dose-response analysis
• Hepatotoxicity mechanisms of plant-derived compounds
• Mycotoxin risk assessment in food chains
• Computational toxicology approaches for in vitro to in vivo extrapolation
• Interindividual variability in chemical metabolism

Recent publications reveal a strong trend toward integrating advanced modeling techniques with experimental toxicology to address regulatory challenges, particularly for low-dose exposures of complex mixtures like pesticides, botanical toxins, and pharmaceuticals. His work consistently targets real-world risk assessment applications with emphasis on human relevance.

Wesseling actively mentors the next generation of toxicologists through PhD supervision:

• Y. Alhejji: Risk assessment of Saudi Arabian food chain contaminants
• F. Widjaja-van den Ende: Alternative testing for pyrrolizidine alkaloid toxicity
• I. Gilbert Sandoval: Mycotoxin risk assessment in maize products
• M. Hiben: Safety evaluation of traditional health food 'Ashkulebya'
• A. Alajlouni: Botanical toxin risk assessment of myristicin

His current active project addresses emerging food safety issues in Saudi Arabia, while completed projects have established methodologies for pyrrolizidine alkaloids, mycotoxins, and botanical food toxins that inform international regulatory frameworks.