Scott McComb

Dr. Scott McComb is an Adjunct Professor at the Department of Biochemistry, Microbiology and Immunology within the Faculty of Medicine at the University of Ottawa. Concurrently, he serves as a Research Officer in the Cancer Immunology Team at the National Research Council of Canada's Human Health Therapeutics division. His research focuses on improving CAR-T cell therapy for cancer through genome editing and understanding immune cell life/death mechanisms.

• Current academic affiliation: University of Ottawa (Faculty of Medicine)
• Research expertise: Cancer Immunology, Programmed Cell Death, CAR-T Therapy
• Email: scott.mccomb@nrc-cnrc.gc.ca

Dr. McComb's work combines in vitro and in vivo approaches with human primary immune cell differentiation studies to analyze cellular immunotherapy dynamics. His recent publications highlight molecular insights into apoptosis/necroptosis regulation and interferon signaling pathways.

Key research themes include:

• CRISPR-based genome editing for T-cell enhancement
• Targeting programmed cell death in immunotherapy
• Mechanistic analysis of immune signaling pathways
• Development of multi-targeted immunotherapies
• Mouse models for cancer therapy validation
• Human immune cell functional assays