About
Sarah Rauscher is an Assistant Professor at the University of Toronto Mississauga (UTM), primarily affiliated with the Department of Chemical and Physical Sciences and also holding a cross-appointment in the Department of Chemistry. Her research focuses on molecular dynamics simulations of biomolecular systems, with a particular emphasis on intrinsically disordered proteins, protein-protein interactions, and enzyme allostery. She employs advanced computational methods to study structural ensembles, biomolecular condensates, and the impact of mutations on protein function.
Her work integrates computational biophysics with biochemical experimentation, addressing topics such as viral protease dynamics, oncogenic mutations in cancer proteins, and the structural basis of elastic biomaterials like elastin. Recent projects include investigating PEG-mCherry interactions under crowding conditions, electric-field effects on protein crystals, and the role of STAT5B mutations in oncogenesis.
Rauscher’s publications span over two decades, demonstrating expertise in force field development (e.g., CHARMM36m), water-mediated allostery, and protein self-assembly mechanisms. Her research bridges fundamental biophysics with translational applications in drug design and biomaterials science.
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