Sangeun Lee

Jun.-Prof. Dr. Sangeun Lee leads a research group focused on developing smart polymeric nanomedicines for drug delivery and gene therapy. Her work exploits disease-specific microenvironments (elevated temperature, reactive oxygen species, pH changes) to create stimuli-responsive materials that control drug release and enable diagnostic functions through dynamic covalent bonds and supramolecular assemblies.

Research Themes

• Stimuli-responsive nanocarriers for cancer/inflammatory diseases
• Biodynamers using dynamic covalent chemistry
• ROS/pH-activated degradation mechanisms
• Bioinspired polymer architectures
• siRNA/mRNA delivery systems
• Diagnostic-therapeutic dual-action materials

Scientific Impact

Lee's publications span polymer chemistry, nanomedicine design, and biomedical applications, with recent work on BODIPY-based tracking of intracellular polymer degradation and arginine-chitosan biodynamers for RNA delivery. Her group actively develops innovative solutions for overcoming biological barriers in drug administration.