Sam Singleton

Sam Singleton is a Research Fellow in Neuroscience, focusing on opioid receptor pharmacology and pain management. He is currently an investigator on the project 'Establishing The Impact Of HSP90 On u Opioid Receptor Function and Analgesic Tolerance (Small Grant)' (2024–2025). His research explores mechanisms of morphine tolerance, opioid receptor signaling pathways, and the role of early life adversity in pain sensitivity. Key areas include β-arrestin2 interactions, c-Src activity, and drug-induced hypersensitivity. His work has been published in journals like Neuropharmacology and Pain, with notable contributions to understanding TRV130 partial agonism and SR-17018 mechanisms. He collaborates with researchers such as Prof. Hales and Dr. Baptista-Hon.