About
Sam Clark is a Postdoctoral Research Associate at the Electron Bio-Imaging Centre (eBIC) of Diamond Light Source, where he has been working since January 2024. He is a member of Dr. Yuriy Chaban's research group, focusing on innovative computational approaches to enhance cryo-electron microscopy (cryo-EM) data analysis, including particle picking, denoising, 3D reconstruction, and post-processing.
His academic journey includes a Ph.D. from the University of Manchester under the supervision of Professor Curtis Dobson, where he investigated antimicrobial peptides using scanning electron microscopy, atomic force microscopy, biophysical assays, and machine learning to establish sequence-activity relationships. Following his doctorate, he held a postdoctoral position at the University of York with Professor Reidun Twarock, studying single-stranded virus assembly and RNA-viral protein interactions, during which he also developed data analysis software for laboratory collaborators.
Clark's research integrates structural biology, computational methods, and machine learning to tackle complex problems in biological imaging. His current work aims to improve the efficiency and accuracy of cryo-EM data processing pipelines, which are critical for high-resolution structural determination of macromolecular complexes.
As part of the eBIC team at Diamond Light Source, he contributes to the center's mission of providing world-leading cryo-EM infrastructure and expertise to the scientific community.
