Rosemarie Terwilliger

Rosemarie Terwilliger is a Researcher in the Department of Psychiatry at Yale School of Medicine. Her work focuses on neurobiological mechanisms underlying mood disorders, stress responses, and neuropharmacology. She investigates how stress impacts neuronal function through molecular pathways involving GABAergic transmission, microglial activation, and neuroinflammation. Her research also explores rapid-acting antidepressant mechanisms and the role of genes/proteins in psychiatric drug responses. Collaborations span multiple institutions, with a focus on translational neuroscience.

Key research areas include:

• Antidepressant mechanisms (ketamine, sestrin modulators)
• Stress-induced neuroplasticity
• Microglia-neuron interactions in depression
• Genetic regulation by antipsychotics
• Role of IGF-1 in exercise-induced antidepressant effects