Romain GUIHO

Romain GUIHO is an Associate Professor at the University of Nantes' UFR Odontology and a Research Associate at Inserm UMRS 1229-RMeS Regenerative Medicine & Skeleton. He leads the JOIN team within Group 2 AGAIN. His research focuses on regenerative medicine, skeletal biology, and oncology, particularly targeting osteoarthritis, pediatric brain tumors, and bone cancers. His work integrates molecular mechanisms of cellular senescence, drug development for senolytics, and preclinical models to understand tumor progression and therapeutic vulnerabilities.

• Affiliations: University of Nantes, Inserm, JOIN team, Group 2 AGAIN
• Key Research Areas: Senescence biology, bone tumors, pediatric gliomas, osteoarthritis therapy

Dr. Guiho’s studies emphasize translational research, exploring how senescence-associated pathways influence tumor behavior and response to therapies. His recent work highlights MAPK pathway modulation, Bcl-xL inhibition, and targeted drug delivery strategies. He collaborates on models of craniopharyngioma, diffuse midline glioma, and jaw osteosarcoma, advancing therapies for hard-to-treat cancers.

Publications span oncology, regenerative medicine, and cellular biology, with a focus on preclinical validation of novel therapeutic agents. His lab also investigates the tumor microenvironment’s role in resistance mechanisms and senolytic efficacy in lung and brain tumors.