Roger Simm

Roger Simm is a Professor and currently serves as Head of Department at the Department of Biosciences, University of Oslo (since 2023). Previously, he was Head of Department at the Institute of Oral Biology (2021-2023) and held the position of Associate Professor there from 2017-2022. His academic journey includes postdoctoral positions at Radiumhospitalet, School of Pharmacy at UiO, and MTC, Karolinska Institutet, where he also completed his PhD in 2007.

Professor Simm's research focuses on understanding the dynamics of bacterial host colonization and infection, with particular emphasis on three key areas: the development and spread of antimicrobial resistance in bacterial communities; host-microbe and microbe-microbe interactions that determine bacterial colonization and pathogenicity; and the regulation of bacterial biofilms and concomitant evolution of antimicrobial resistance. His work aims to translate these findings into novel therapeutics and treatment regimens that can prevent bacterial infections or reduce their damaging effects.

Analysis of his recent publications reveals a consistent research trajectory centered on bacterial signaling mechanisms, particularly cyclic dinucleotide signaling (c-di-GMP and c-di-AMP), and their roles in biofilm formation, antimicrobial resistance, and bacterial pathogenesis. His work spans both fundamental molecular mechanisms and applied research with implications for food safety, veterinary medicine, and human health, reflecting a strong One Health perspective. The publications demonstrate expertise in advanced analytical techniques including LC-MS/MS for nucleotide analysis, bacterial genomics, and molecular characterization of resistance mechanisms.

As Head of Department at the Department of Biosciences, Professor Simm leads the Research Group on Dynamics of Bacterial Colonization. His leadership extends to overseeing research activities, mentoring junior researchers, and directing the department's strategic research initiatives in microbiology and related fields. His research group maintains strong connections with both clinical and veterinary settings, reflecting the translational nature of their work.