Roger B. Sutton

Roger B. Sutton is a Professor in the Department of Cell Physiology and Molecular Biophysics at Texas Tech University Health Sciences Center's School of Medicine. His research focuses on the structural biology of membrane proteins, particularly C2 domains, using X-ray crystallography to investigate their roles in membrane fusion and repair processes.

Dr. Sutton's primary research interests include:

• Structural analysis of C2 domains in synaptotagmin and dysferlin
• Mechanisms of membrane fusion and repair
• Molecular basis of muscular dystrophy related to dysferlin mutations
• Autoimmune disorders related to DNASE1L3 function
• Protein structure-function relationships in membrane-associated proteins

His recent publications show a progression from structural studies of C2 domains toward understanding their roles in human disease, particularly muscular dystrophy and autoimmune disorders. This evolution demonstrates how his fundamental structural work has increasingly connected to clinically relevant questions.

Dr. Sutton's notable research contributions include:

• Solving the crystal structure of human synaptotagmin C2 domains
• Determining the 2.0Å structure of dysferlin's C2A domain
• Elucidating the molecular basis of synaptotagmin-1 associated neurodevelopmental disorders
• Investigating the role of DNASE1L3 in autoimmune disease pathogenesis

His lab operates as part of the Center for Membrane Research at Texas Tech, utilizing advanced structural biology techniques to investigate membrane protein function. Dr. Sutton maintains active collaborations across multiple disciplines, as evidenced by his diverse publication record spanning neuroscience, structural biology, immunology, and cell biology. His work continues to bridge fundamental structural insights with potential therapeutic applications for muscular dystrophy and autoimmune disorders.