About
Dr. Robert Harkness is an Assistant Professor in the Department of Molecular and Cellular Biology at the University of Guelph. His research focuses on structural dynamics of biomolecules, particularly proteases and nucleases, in cellular homeostasis and gene expression regulation.
- Department: Molecular and Cellular Biology
- Techniques: NMR spectroscopy, ITC, fluorescence, hydrodynamics, computational modeling
Research interests include:
- Protease molecular machines in protein recycling
- Nuclease regulation of mRNA decay via deadenylation
- Non-canonical nucleic acid structures (e.g., G-quadruplexes)
- Impact of epigenetic modifications on nucleic acid dynamics
The lab's biophysical approach integrates experimental measurements with quantitative modeling to elucidate molecular mechanisms in health and disease contexts.
Recent publications examine:
- DegP protease cage dynamics in protein quality control
- Deadenylase structural regulation of mRNA homeostasis
- Energy landscapes of guanine quadruplex folding
Trainees gain multidisciplinary skills applicable to academic, industrial, and government careers.
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